Cape Town - South Africa's Kevin Anderson bowed out of the Australian Open on Thursday after a second round defeat to 29th-seeded American Taylor Fritz.
Fritz, 22, came back from two sets down to win 4-6, 6-7 (5/7), 7-6 (7/4), 6-2, 6-2.
It appeared as though Anderson, 33, was coasting when he led by two sets and 4-2 in the third set, only for the American to stage a remarkable comeback.
Fritz broke back in the third set and went on to win it on a tie-break, before cruising through the final two sets.
Anderson, a two-time Grand Slam finalist, is currently ranked No 120 in the ATP rankings after an injury-riddled 2019 and will be gutted at letting slip a big opportunity to move deeper into the year's first Grand Slam.
The 2.03m tall South African also lost at the second round stage of last year's Australian Open when he was beaten by Britain's Kyle Edmund.
Fritz will next face Austrian fifth seed Dominic Thiem - a player Anderson would not have minded facing as the South African boasts a 7-2 win-loss record against Thiem.
South Africa's other singles contestant, Lloyd Harris, lost in the first round to Argentine 14th-seed Diego Schwartzman.
In the men's doubles, South Africa's Raven Klaasen and his new Austrian partner Oliver Marach are through to the second round where they will play little-known Argentine Andres Molteni and his Monagasque partner, Hugo Nys on Friday.